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Related Experiment Videos

Bowenoid papulosis showing polyclonal nature

H Inagaki1, M Nonaka, T Eimoto

  • 1Department of Pathology, Nagoya City University Medical School, Japan.

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
|October 24, 1998
PubMed
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Bowenoid papulosis (BP), a type of squamous intraepithelial lesion (SIL), shows a polyclonal nature, indicating clinicopathologic heterogeneity. This finding challenges previous assumptions about the monoclonal origin of vulvar SILs.

Area of Science:

  • Gynecologic Pathology
  • Dermatopathology
  • Oncology

Background:

  • Bowenoid papulosis (BP) presents clinically as benign-looking lesions on the external genitalia, histologically resembling high-grade squamous intraepithelial lesions (SILs).
  • A strong association exists between BP and high-risk human papillomavirus (HPV) types, particularly HPV 16, leading to its general classification within the SIL category.
  • Despite classification, controversy persists regarding the precise nature and origin of BP.

Observation:

  • This study investigated the clonality of bilateral BP lesions in a 15-year-old female using polymerase chain reaction-based clonal analysis of the androgen receptor gene (HUMARA).
  • Analysis of DNA from each BP lesion revealed a random X-chromosome inactivation pattern.

Findings:

  • The observed random X-chromosome inactivation pattern indicates a polyclonal origin for the analyzed BP lesions.

Related Experiment Videos

  • This is the first report demonstrating polyclonality in a SIL diagnosed as BP, contrasting with recent reports of monoclonal vulvar SIL proliferation.

    • Implications:

    • The findings suggest that BP may represent a clinicopathologically heterogeneous group of lesions within vulvar SILs.
    • This heterogeneity could impact understanding of BP pathogenesis and inform diagnostic and treatment strategies.
    • Further research into the diverse origins of vulvar SILs is warranted.