Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ovarian follicular dynamics: from basic science to clinical practice

A Pellicer1, P Gaitán, F Neuspiller

  • 1Instituto Valenciano de Infertilidad, Valencia University School of Medicine, Spain. ivi@futurnet.es

Journal of Reproductive Immunology
|October 24, 1998
PubMed
Summary

Managing low responders (LR) in assisted reproduction (AR) is challenging. This study found similar oocyte and embryo quality in younger and older LR compared to normal responders, despite vascular resistance in LR.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychosocial and environmental motivational key factors behind the parenthood desire in infertile couples at the time of COVID-19.

Journal of assisted reproduction and genetics·2024
Same author

Severe pulmonary hypertension and circulatory failure associated with Congenital syphilis. Case report.

Journal of neonatal-perinatal medicine·2024
Same author

RISEinFAMILY project: the integration of families at neonatal intensive care units (NICUs) to empower them as primary caregivers: study protocol for a stepped wedge cluster controlled trial.

Trials·2024
Same author

Correction to: The HERA (Hyper‑response Risk Assessment) Delphi consensus for the management of hyper‑responders in in vitro fertilization.

Journal of assisted reproduction and genetics·2023
Same author

The HERA (Hyper-response Risk Assessment) Delphi consensus for the management of hyper-responders in in vitro fertilization.

Journal of assisted reproduction and genetics·2023
Same author

Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression.

Frontiers in molecular biosciences·2023

Area of Science:

  • Reproductive Medicine
  • Infertility Research
  • Ovarian Physiology

Background:

  • Low ovarian response (LR) is a significant challenge in assisted reproduction (AR), affecting both aging and younger patients.
  • While ovarian aging impacts granulosa cells, oocytes, and embryos, young LR primarily show affected inhibin production.
  • The study investigates whether oocyte and embryo quality differ between age groups of LR and normal responders (NR).

Purpose of the Study:

  • To compare oocyte and embryo quality in younger and older low responders (LR) versus normal responders (NR).
  • To explore potential vascular factors contributing to LR using Doppler ultrasound.
  • To discuss current and future treatment strategies for LR in AR.

Main Methods:

  • Retrospective analysis of patient files.

Related Experiment Videos

  • Comparison of oocyte and embryo quality between younger LR, older LR, and NR groups.
  • Color Doppler vaginal ultrasound to assess pulsatility index (PI) and resistance index (RI) in LR versus NR.

    • Main Results:

    • Oocyte and embryo quality were found to be similar between younger LR, older LR, and NR.
    • LR exhibited increased pulsatility index (PI) and resistance index (RI) compared to NR, indicating vascular resistance.
    • Ovum donation shows high cumulative birth rates (>85% with four attempts) for LR.

    Conclusions:

    • Oocyte and embryo quality are not significantly affected by age in low responders (LR) compared to normal responders (NR).
    • Increased vascular resistance may be a factor in low ovarian response.
    • Future treatments for LR may involve new technologies like recombinant gonadotropins and growth factors.