Related Experiment Video
Updated: Aug 17, 2026

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage
Published on: February 15, 2020
Oxidative injury in the nervous system
1Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104-4283, USA.
Abstract:
A free radical is a highly reactive chemical species that can react with organic macromolecules leading to cell and tissue damage and consequent functional disruption. Free radical or oxidative injury is increasingly recognized as an important factor in the pathophysiology of many human diseases, including those that affect the nervous system. This review summarizes important evidence implicating oxidative injury in the pathogenesis and progression of many important neurological disorders, including cerebrovascular disease, epilepsy, amyotrophic lateral sclerosis, and Huntington's disease. Results of controlled clinical trials of various antioxidant therapies in neurological disease performed to date are also highlighted.
Related Concept Videos
Neurogenesis and Regeneration of Nervous Tissue
Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Cellular Injury I: Introduction
Cellular Injury II: Classification
Cellular Injury IV: Necrosis
Secondary Spinal Cord Injury llI: Pathophysiology

