Related Experiment Video
Updated: Aug 19, 2026
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
Comparison of different animal models of stress reveals a non-monotonic effect
1Dept. of Biological & Medical Psychology, University of Bergen Arstadveien 21 N-5009 Bergen, Norway. murison@psych.uib.no
Abstract:
A handling-only control and two footshocked stressed groups for which the numbers of footshocks, 10 or 100, were determined by different proposed clinically relevant models were compared after a 15-day delay on the alerting-immobility response to a sudden reduction in noise. Only the 10-shocks group showed a significantly increased level of alert-immobility. The implications of this non-monotonicity of effects of increasing stress for modelling and scientific practice are considered.
