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Multiple skin cancers associated with hydroxyurea therapy

P J Best1, R M Petitt

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic Rochester, Minnesota 55905, USA.

Mayo Clinic Proceedings
|October 27, 1998
PubMed
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Long-term hydroxyurea use increases the risk of developing multiple skin cancers, even after treatment cessation. Clinicians should monitor patients for these risks and implement screening protocols.

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Hydroxyurea is a medication commonly used for myeloproliferative diseases.
  • Long-term use of hydroxyurea has been anecdotally linked to cutaneous malignancies.

Observation:

  • Two cases of patients on long-term hydroxyurea therapy developed multiple skin tumors.
  • Skin cancers appeared late in the course of therapy and even after discontinuation.

Findings:

  • Hydroxyurea therapy is associated with an increased risk of multiple cutaneous cancers.
  • The development of skin cancers can occur years after hydroxyurea treatment has ended.

Implications:

  • Clinicians must maintain awareness of the heightened risk of skin cancer in patients using hydroxyurea.

Related Experiment Videos

  • Regular skin cancer screenings and preventive measures are crucial for patients on long-term hydroxyurea therapy.