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Plasmatic amino acids in kidney transplantation in children
1Paediatric Intensive Care Unit, La Paz Children's Hospital, Madrid, Spain.
Insights
Renal transplantation in children with chronic kidney failure normalized plasma amino acid levels within 72 hours. This study tracked amino acid profiles, revealing significant shifts post-transplant.
Area of Science:
- Pediatric Nephrology
- Biochemistry
- Transplantation Medicine
Background:
- Children with chronic kidney failure exhibit altered plasma amino acid profiles.
- These alterations may impact post-transplant recovery and outcomes.
Purpose of the Study:
- To investigate the dynamic changes in plasma amino acid levels in pediatric patients following renal transplantation.
- To correlate amino acid profile evolution with the recovery of renal function post-surgery.
Main Methods:
- Plasma amino acid profiles were analyzed in 10 children before and at multiple time points (0-72 hours) after renal transplantation.
- Measurements included specific amino acids, branched-chain amino acids (BCAA), aromatic amino acids (AAA), and essential amino acids (EAA).
- Amino acid levels were compared to control children and correlated with renal function parameters.
Main Results:
- Pre-transplant, elevated levels of glutamic acid, hydroxyproline, citrulline, and arginine were observed.
- Conversely, levels of serine, glutamine, threonine, tyrosine, valine, leucine, tryptophan, BCAA, AAA, and EAA were significantly decreased pre-transplant.
- Within 72 hours post-transplantation, most amino acid levels, except tryptophan and arginine, normalized, mirroring improvements in renal function.
Conclusions:
- Renal transplantation rapidly corrects plasma amino acid imbalances in children with chronic kidney failure.
- The normalization of amino acid profiles suggests improved metabolic function and supports recovery after transplantation.
Abstract:
We studied the evolution of plasma amino acid levels in children with chronic kidney failure after undergoing a renal transplantation. Plasma amino acid profile was studied in 10 children just before surgery, at admission in paediatric intensive care unit and 4, 8, 12, 24, 48 and 72 h after transplantation. Previous to the graft, plasma levels of glutamic acid (p < 0.01), hydroxyproline (p < 0.01), citrulline (p < 0.01) and arginine (p < 0.05) were significantly increased, whereas plasma levels of serine (p < 0.01), glutamine (p < 0.03), threonine (p < 0.01), tyrosine (p < 0.01), valine (p < 0.01), leucine (p < 0.01), tryptophan (p < 0.01), branched amino acids (BCAA) (p < 0.01), aromatic amino acids (AAA) (p < 0.01) and essential amino acids (EAA) (p < 0.01) were decreased in relation to control children. The amino acid profile evolution run parallel to the settle down of renal function parameters. Within 72 h after surgery, even before in some cases, all amino acids except tryptophan and arginine reached normal levels.