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St John's Wort (Hypericum perforatum)--a herbal antidepressant
1Department of Psychiatry, University of Munich, Germany.
Current Medical Research and Opinion
|October 27, 1998
Summary
St John's wort (Hypericum perforatum L.) extract shows significant antidepressant effects for mild to moderate depression. This herbal remedy is well-tolerated, making it suitable for outpatient use.
Area of Science:
- Pharmacology
- Herbal Medicine
- Psychiatry
Background:
- Clinical studies suggest whole extract of St John's wort (Hypericum perforatum L.) possesses antidepressant properties.
- Herbal antidepressants are gaining attention for treating mood disorders.
Purpose of the Study:
- To evaluate the efficacy and tolerability of St John's wort for mild to moderate depression.
- To assess its suitability for outpatient treatment and in elderly patients.
Main Methods:
- Analysis of pooled data from clinical studies.
- Review of treatment outcomes and adverse drug reactions.
Main Results:
- St John's wort demonstrates a 60-70% response rate in mild to moderate depression.
- Preparations are generally well-tolerated with minimal adverse effects, primarily mild subjective symptoms.
- High patient compliance is noted due to good tolerability and efficacy.
Conclusions:
- St John's wort preparations are effective and well-tolerated for mild to moderate depression, suitable for outpatient settings.
- Elderly patients also exhibit good tolerability.
- If no improvement occurs after 4-6 weeks of high-dose treatment (900 mg/day), switching to a conventional antidepressant is recommended.