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Updated: Aug 12, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Two giant basal cell carcinomas presenting simultaneously in the same patient, one resulting in lower extremity limb
M Mainella1, W T Majewski, P Latkovich
1Department of Surgery, Berkshire Medical Center, Pittsfield, MA 01201, USA.
Abstract:
Giant basal cell carcinomas are a rare form of the most common malignant neoplasm of the skin. They are commonly found on the trunk and display a more aggressive behavior, resulting in local invasion and metastasis. Giant basal cell carcinomas that reach a critical size of 10 cm in diameter almost always present with metastases. We present an 82-year-old woman who presented with two giant basal cell carcinomas of critical size-one that occurred on the lower extremity and resulted in limb loss without any sign of metastasis.
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