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Angiogenesis in P- and E-selectin-deficient mice
D W Hartwell1, C E Butterfield, P S Frenette
1Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA.
Objectives:
Several observations reported earlier indicated that the selectins, in particular E-selectin, might be involved in angiogenesis; however, mice deficient in the endothelial selectins develop normally. To clarify the role of endothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice.
Methods:
Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor alpha were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice.
Results:
The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice.
Conclusion:
The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.