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Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
1Dept of Medical Genetics, Max-Delbrück-Centrum for Molecular Medicine, Berlin, Germany. cbirch@mdc-berlin.de
Trends in Cell Biology
|October 28, 1998
Abstract:
A number of developmental processes that involve cell migration, growth or morphogenesis depend on extracellular signals. A molecule that provides such signals, known as hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in recent years because of its distinct structure, mechanism of activation and important roles throughout embryogenesis. This review discusses the main features of HGF/SF and its receptor, the product of the c-met protooncogene, and their role in embryogenesis.