Signal sequences: more than just greasy peptides
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Updated: Aug 19, 2026

Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells
Published on: November 6, 2021
1Institut für Biochemie II, ETH-Zentrum, Zürich, Switzerland. bruno.martoglio@bc.biol.ethz.ch
Abstract:
Export signal sequences target newly synthesized proteins to the endoplasmic reticulum of eukaryotic cells and the plasma membrane of bacteria. All signal sequences contain a hydrophobic core region, but, despite this, they show great variation in both overall length and amino acid sequence. Recently, it has become clear that this variation allows signal sequences to specify different modes of targeting and membrane insertion and even to perform functions after being cleaved from the parent protein. This review argues that signal sequences are not simply greasy peptides but sophisticated, multipurpose peptides containing a wealth of functional information.
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