Detection of enteroviral sequence in endomyocardial tissues from patients with cardiac diseases in northern Brazil

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Published on: February 28, 2018

M de L Gomes1, H Kopecka, A G Ferreira Júnior

  • 1Instituto Evandro Chagas, Fundação Nacional de Saúde, Belém, Brasil.

Revista Da Sociedade Brasileira De Medicina Tropical
|October 28, 1998
PubMed

Insights

This pilot study detected enterovirus sequences in cardiac tissues from Amazon patients with heart disease. Findings suggest enteroviruses may contribute to conditions like myocarditis, necessitating further research.

Area of Science:

  • Cardiology
  • Virology
  • Infectious Diseases

Background:

  • Cardiac diseases pose a significant health burden globally.
  • Enteroviruses are known pathogens implicated in various human illnesses.
  • The role of enteroviruses in cardiac pathology within the Amazon region is understudied.

Purpose of the Study:

  • To investigate the presence of enterovirus sequences in cardiac tissues of patients from the Amazon region.
  • To explore the potential link between enteroviruses and cardiac diseases in this population.

Main Methods:

  • Endomyocardial biopsies were obtained from patients with cardiac diseases.
  • Reverse Transcription Polymerase Chain Reaction (RT-PCR) was employed to detect enterovirus RNA.
  • Six cardiac tissue samples from three patients were analyzed.

Main Results:

  • RT-PCR analysis revealed enterovirus sequences in 3 out of 6 analyzed samples.
  • The study identified a 50% detection rate of enteroviruses in the pilot cohort.
  • No specific correlation with clinical presentation was detailed in this preliminary report.

Conclusions:

  • Preliminary findings suggest enteroviruses may play a role in the etiology of cardiac diseases, particularly myocarditis, in the Amazon.
  • Further comprehensive studies are warranted to confirm these initial observations.
  • This research highlights the need for expanded etiological investigations in the region.

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