Regulation of gene expression by trans-synaptic activity: a role for the transcription factor NF-kappa B

Earlier studies in the sympathetic ganglion have led to the proposal that adaptation of transcription to trans-synaptic activity is controlled by a signal transduction pathway featuring a transcription factor which translocates to the nucleus upon its release from the post-synaptic membrane by after-hyperpolarization. In light of recent progress, it is proposed here that NF-kappa B constitutes the postulated transcription factor.