Transcriptional pathways for synapse-specific, neuregulin-induced and electrical activity-dependent transcription

Innervation-dependent expression of acetylcholine receptor (AChR) genes in skeletal muscle is mediated by multiple transcriptional pathways. One pathway leads to activation of AChR genes selectively in synaptic nuclei and requires an Ets binding site that binds GABP. A second pathway leads to repression of AChR transcription in nuclei throughout the myofiber and requires inactivation of E-box-binding proteins, including myogenic bHLH proteins. Taken together, these studies indicate that separate pathways regulate innervation-dependent transcription.