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TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo
T Debeir1, H U Saragovi, A C Cuello
1Department of Pharmacology & Therapeutics, McGill University, Montreal, PQ, Canada.
Journal of Physiology, Paris
|October 28, 1998
Abstract:
Cholinergic neurons are known to respond in vivo to the administration of nerve growth factor (NGF) by a prominent and selective increase of choline acetyl transferase activity and by cholinergic synaptogenesis in the rat brain. By using a synthetic TrkA antagonist we demonstrated that endogenously produced NGF is involved in the continual re-modeling of cholinergic neuronal connections during adulthood, acting through TrkA receptors.