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Coagulation studies and platelet function after somatostatin infusion

H Rasche, S Raptis, R Scheck

    Klinische Wochenschrift
    |October 15, 1976
    PubMed
    Summary
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    Short-term somatostatin (GIF) administration may temporarily affect platelet count and aggregation in healthy individuals. However, long-term use in patients showed no significant bleeding risks and even aided in stopping gastric bleeding.

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Hematology

    Background:

    • Somatostatin (GIF) is a peptide hormone with diverse physiological roles.
    • Its impact on hemostasis, particularly in clinical settings, requires thorough investigation.

    Purpose of the Study:

    • To evaluate the effects of short- and long-term somatostatin (GIF) administration on human hemostatic function.
    • To assess the clinical relevance of any observed hemostatic changes.

    Main Methods:

    • Healthy volunteers received 250 mug GIF bolus injection followed by 250 mug/h infusion for 3 hours.
    • Two patients with gastric hemorrhage received 67-120 hour infusions.
    • Hemostatic parameters including platelet count, aggregation, bleeding time, and coagulation factors were measured.

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    Main Results:

    • Short-term GIF administration caused transient, physiologically normal decreases in platelet count and aggregation.
    • No significant hemostatic defects were observed in patients receiving long-term GIF.
    • One patient experienced cessation of peptic ulcer bleeding within 60 minutes of GIF infusion.

    Conclusions:

    • Somatostatin (GIF) administration at the tested dosages does not appear to cause clinically significant bleeding tendencies.
    • The drug may have a beneficial effect in controlling certain types of gastrointestinal bleeding.