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Apparent acaridal dermatitis in a C57BL/6 Nya mouse colony
Laboratory Animal Science
|October 1, 1976
Summary
A Myobia musculi mite infestation caused severe dermatitis in black mice, leading to self-mutilation and death. Treatment with a dichlorvos-ronnel combination eradicated the mites, preventing further dermatitis.
Area of Science:
- Veterinary Dermatology
- Immunology
- Parasitology
Background:
- Dermatitis in a mouse breeding colony was characterized by intense pruritus, self-mutilation, and mortality.
- The suspected cause was infestation with the ectoparasitic mite, Myobia musculi.
Purpose of the Study:
- To characterize dermatitis caused by Myobia musculi in mice.
- To evaluate the efficacy of a dichlorvos-ronnel treatment for mite eradication.
- To investigate the immunological response to mite infestation.
Main Methods:
- Clinical observation of dermatitis and pruritus.
- Identification of Myobia musculi as the causative agent.
- Treatment with a liquid dichlorvos-ronnel combination applied to bedding.
- Assessment of immunological parameters including plasma cells, serum immunoglobulins, and granulocytes.
Main Results:
- Myobia musculi infestation led to skin ulceration, serum exudation, and secondary immune responses (lymph node and spleen hyperplasia, increased plasma cells, serum immunoglobulins, and circulating granulocytes).
- The dichlorvos-ronnel treatment successfully eliminated Myobia musculi, reducing dermatitis incidence to zero.
- Pathogenicity of Myobia musculi varied among different mouse strains, sexes, ages, and individual sensitivities.
Conclusions:
- Myobia musculi is a significant pathogen causing severe dermatitis in susceptible mouse strains.
- A dichlorvos-ronnel combination is an effective treatment for Myobia musculi infestation in mice.
- Mouse strain, sex, age, and individual sensitivity influence the severity of Myobia musculi infestation and associated dermatitis.