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[Multicenter trial of Enterococcus antibiotic susceptibility]
S V Sidorenko1, S P Rezvan, S A Grudinina
1National Research Centre of Antibiotics, Moscow.
Abstract:
Antibiotic susceptibility of 446 Enterococcus isolates from 9 medical centres of Moscow and St. Petersburg was tested. Among the isolates 386 belonged to E.faecalis, 48 to E.faecium and 12 to the other species. All the isolates were susceptible to vancomycin. As for E.faecalis 84 and 85 per cent of the isolates were susceptible to ampicillin and ampicillin/sulbactam respectively (no production of beta-lactamases), the frequency of high resistance to aminoglycosides amounted to 44 per cent with respect to streptomycin and to 25 per cent with respect to gentamicin, 75 per cent of the isolates was susceptible to ciprofloxacin. As for E.faecium and the rare species of Enterococcus more than 70 per cent of the isolates was resistant to ampicillin and ampicillin/sulbactam, the frequency of high resistance to aminoglycosides exceeded 60 per cent, 17 and 25 per cent of the isolates were susceptible to ciprofloxacin.
Insights
All Enterococcus isolates tested were susceptible to vancomycin. However, resistance varied, with E. faecalis showing susceptibility to ampicillin and ampicillin/sulbactam, while E. faecium exhibited higher resistance to these antibiotics.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- Enterococcus species are significant nosocomial pathogens.
- Antibiotic resistance in Enterococcus is a growing global health concern.
- This study assessed Enterococcus isolates from major Russian medical centers.
Purpose:
- To determine the antibiotic susceptibility patterns of Enterococcus isolates in Moscow and St. Petersburg.
- To compare the resistance profiles between Enterococcus faecalis and Enterococcus faecium.
- To evaluate susceptibility to key antibiotics including vancomycin, ampicillin, ampicillin/sulbactam, aminoglycosides, and ciprofloxacin.
Summary:
- A total of 446 Enterococcus isolates (386 E. faecalis, 48 E. faecium, 12 other species) were analyzed.
- All isolates demonstrated susceptibility to vancomycin.
- E. faecalis showed high susceptibility to ampicillin (84%) and ampicillin/sulbactam (85%), with 75% susceptible to ciprofloxacin. Resistance to streptomycin and gentamicin was 44% and 25%, respectively.
- E. faecium and other Enterococcus species displayed over 70% resistance to ampicillin and ampicillin/sulbactam, with aminoglycoside resistance exceeding 60%. Susceptibility to ciprofloxacin was lower at 17% and 25%.
Impact:
- Highlights the continued effectiveness of vancomycin against Enterococcus in this region.
- Reveals differential resistance patterns between E. faecalis and E. faecium, informing treatment strategies.
- Suggests potential challenges in treating infections caused by E. faecium and other Enterococcus species with beta-lactams and aminoglycosides.
- Provides crucial data for antimicrobial stewardship programs in Russian healthcare settings.
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