Daily hemodialysis: dialysis for the next century

There are currently over 150 patients receiving daily hemodialysis in over 12 centers worldwide. The experiences of over 200 daily hemodialysis patients spanning 30 years have been reviewed. The reports uniformly describe subjective and objective improvements. There are decreased symptoms during and after dialysis, improved functional status, and better quality-of-life ratings. There are improved nutritional indices, improved blood pressure with fewer blood pressure medications, and improved hematocrit with reduced transfusion or eythropoietin requirements. There also appear to be economic advantages, related to the significant reductions in the need for recombinant human erythropoietin and blood pressure medications. Early data suggest that there may be a significant decrease in days of hospitalization for very ill patients as well. This is important clinically and financially when the global costs of caring for dialysis patients are considered. Substantial issues remain before daily hemodialysis will be widely accepted. These include logistical problems (additional time for transportation, set up and disinfection), economic problems (increased supply costs or labor associated with more frequent treatments), and medical problems (deficiency syndromes and blood access). Technological improvements are close to overcoming many of the recognized problems, although additional payor education, research into deficiency syndromes, and an even greater focus on creating natural arterio-venous fistulae all need to occur before daily hemodialysis is more widely accepted. We are convinced, however, that daily dialysis will be increasingly used in the next century because it is more physiologic, makes many patients feel much better, produces better outcomes, and decreases overall cost for end-stage renal disease patients compared with current dialysis regimes.