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Is ouabain produced by the adrenal gland?
R H Foster1, H Prat, I Rothman
1Department of Physiology and Biophysics, Faculty of Medicine, University of Chile, Santiago.
General Pharmacology
|October 29, 1998
Summary
Endogenous ouabain, a compound related to ouabain, is found in adrenal cortex cells. Its production may be increased by angiotensin II and adrenocorticotropin, suggesting secretion by the adrenal zona glomerulosa.
Area of Science:
- Endocrinology
- Molecular Biology
- Cell Biology
Background:
- Ouabain, a cardiac glycoside, has a related stereoisomer known as endogenous ouabain.
- Endogenous ouabain has been detected in adrenal cortex tissue and cell cultures.
- Adrenocortical cells are the source of endogenous ouabain.
Purpose of the Study:
- To review experimental evidence regarding endogenous ouabain secretion.
- To investigate the role of the adrenal zona glomerulosa in producing endogenous ouabain.
Main Methods:
- Review of existing experimental data.
- Analysis of studies on adrenal cortex tissue and cell cultures.
- Examination of factors influencing aldosterone secretion.
Main Results:
- Endogenous ouabain is present in adrenal cortex tissue and culture medium.
- Angiotensin II and adrenocorticotropin appear to stimulate endogenous ouabain production.
- Evidence suggests endogenous ouabain is secreted by the adrenal zona glomerulosa.
Conclusions:
- The adrenal zona glomerulosa is a likely source of endogenous ouabain secretion.
- Hormonal factors like angiotensin II and adrenocorticotropin may regulate endogenous ouabain production.