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Silica urolithiasis without magnesium trisilicate intake

O Ichiyanagi1, I Sasagawa, Y Adachi

  • 1Department of Urology, Yamagata University School of Medicine, Yamagata, Japan.

Urologia Internationalis
|October 30, 1998
PubMed
Summary

Silica stones in the kidneys can form without the patient taking magnesium trisilicate antacids. This suggests other causes for silicate urolithiasis may exist.

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Area of Science:

  • Nephrology
  • Urology
  • Mineralogy

Background:

  • Silicate urolithiasis is a rare condition often associated with the oral intake of magnesium trisilicate antacids.
  • The exact pathogenesis and contributing factors for silicate stone formation require further investigation.

Observation:

  • Two cases of silicate urolithiasis are presented in elderly women without a history of magnesium trisilicate consumption.
  • One patient presented with bilateral renal stones, while the other had unilateral stones.

Findings:

  • Infrared spectrophotometry analysis revealed silicate composition in stones from both patients.
  • In one case, silicate stones were found alongside calcium oxalate stones.
  • In the second case, a stone was composed of a mixture of silicate and other unspecified matrices.

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Implications:

  • These findings challenge the established link between magnesium trisilicate antacid use and silicate urolithiasis.
  • The study suggests that other, yet unidentified, factors may contribute to the formation of silicate kidney stones.
  • Further research is warranted to elucidate the diverse etiologies of silicate urolithiasis.