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[Superoxide, nitric oxide and peroxynitrite]

N Fukuyama¹, H Nakazawa

¹Department of Physiology, School of Medicine, Tokai University, Kanagawa, Japan.

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

|October 30, 1998

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Superoxide can cause cell injury, but new findings on nitric oxide (NO) require re-evaluating conditions previously blamed on superoxide. The reaction between superoxide and NO produces peroxynitrite, a potent oxidant involved in various injuries.

Area of Science:

Biochemistry
Cell Biology
Pathology

Context:

Evidence shows superoxide's injurious effects.
Cells generate nitric oxide (NO).
Superoxide and NO react to form peroxynitrite.

Purpose:

Re-examine pathological conditions attributed to superoxide.
Investigate the role of peroxynitrite in disease.
Highlight peroxynitrite-related injuries.

Summary:

Reviews pathological conditions involving superoxide, nitric oxide (NO), and peroxynitrite.
Discusses the formation of peroxynitrite from superoxide and NO.
Presents examples of injuries caused by peroxynitrite.

Impact:

Related Experiment Videos

Shifts understanding of oxidative stress-related diseases.
Identifies peroxynitrite as a key mediator in cellular damage.
Provides insights into mechanisms of various pathological conditions.