Pacemaker-mediated polymorphic ventricular tachycardia
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Updated: Oct 28, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
1Division of Cardiology, University of Florida, Jacksonville, USA.
Abstract:
A patient with refractory bradycardia dependent polymorphic ventricular tachycardia (PMVT) underwent permanent pacemaker placement for suppression of her arrhythmia. Following implant, the patient had recurrent PMVT. Interrogation of the device revealed a factory programmed feature (+ PVARP on PVC) designed to prevent pacemaker-mediated tachycardia that led to cycle length variability and subsequent arrhythmia recurrence. This feature was deactivated and the patients' arrhythmia did not recur.
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