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Papillary eccrine adenoma: an ultrastructural and immunohistochemical study
J G Guccion1, R H Patterson, R Nayar
1Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA.
Ultrastructural Pathology
|October 30, 1998
Summary
A rare benign skin tumor, eccrine duct adenoma, was identified in a thigh lesion. Microscopic and ultrastructural analysis confirmed its origin from eccrine sweat glands.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Cutaneous adnexal tumors represent a diverse group of neoplasms.
- Eccrine duct adenoma is a rare benign neoplasm originating from the eccrine sweat gland's ductal system.
Observation:
- A 45-year-old male presented with a long-standing, solitary, nonulcerated lesion on the right thigh.
- Histopathological examination revealed a well-circumscribed intradermal tumor composed of dilated tubules with intraluminal papillations.
Findings:
- Ultrastructural analysis demonstrated differentiation towards both eccrine ductal and secretory coil components.
- Immunohistochemical staining was positive for S-100 protein, CEA, EMA, and vimentin, supporting the dual differentiation.
Implications:
- This case highlights the importance of comprehensive diagnostic methods, including ultrastructural and immunohistochemical analysis, for accurate classification of rare skin tumors.
- Understanding the differentiation pathways of eccrine tumors aids in accurate diagnosis and management of cutaneous neoplasms.
