Acute myeloblastic leukemia with trilineage myelodysplasia and CD34+ blast cells with abnormal chromatin clumping

Abnormal chromatin clumping can be observed in myelodysplastic syndromes, myeloproliferative syndromes, acute leukemias and the abnormal chromatin clumping syndrome. It occurs mainly in mature and semimature blood cells. We report a case of acute myeloid leukemia with trilineage myelodysplasia (AML/TMDS) in which there was chromatin clumping in blast cells.