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Synthesis and antimicrobial activity of a dihydroampicillin and a dihydrocephalexin
A I Hashem1, M E Shaban, R Abdel-Aziz
1Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Archiv Der Pharmazie
|October 30, 1998
Abstract:
A dihydroampicillin (3) and a dihydrocephalexin (4) have been synthesized by condensing alpha-(cyclohexa-1, 3-dienyl)glycyl chloride with 6-aminopenicillanic acid (1) and 7-deacetoxycephalosporanic acid (2) respectively. The two antibiotics obtained show enhanced antimicrobial activity towards certain bacterial strains compared with ampicillin and cephalexin.