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Related Experiment Videos

Methysergide

S D Silberstein1

  • 1Jefferson Headache Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.

Cephalalgia : an International Journal of Headache
|October 30, 1998
PubMed
Summary
This summary is machine-generated.

Methysergide is an effective migraine prophylaxis drug, acting as a serotonin receptor antagonist and agonist. Due to potential serious side effects like fibrosis, it is reserved for severe, resistant migraine cases.

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Area of Science:

  • Pharmacology
  • Neurology
  • Internal Medicine

Background:

  • Methysergide, an ergot alkaloid derivative, is a serotonin (5HT) receptor antagonist and 5HT1 agonist.
  • Its efficacy in migraine prophylaxis is supported by clinical studies, particularly in resistant cases.

Purpose of the Study:

  • To review the efficacy and safety profile of methysergide for migraine prophylaxis.
  • To highlight its mechanism of action and potential synergistic effects.

Main Methods:

  • Review of open and controlled clinical studies on methysergide.
  • Analysis of its pharmacological properties and contraindications.

Main Results:

  • Methysergide demonstrates efficacy in migraine prophylaxis, potentially more so in severe, high-frequency cases.

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  • It may offer synergistic benefits when combined with ergotamine or dihydroergotamine (DHE) for acute attacks.

    • Conclusions:

    • Methysergide is a valuable option for severe migraines unresponsive to other treatments.
    • Significant risks, including retroperitoneal, pleural, and heart valve fibrosis (1 in 5,000), necessitate its reserved use.