Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective brain cooling and thermoregulatory set-point

M Cabanac1

  • 1Département de Physiologie, Faculté de Médecine, Université Laval Québec, Canada.

Journal of Basic and Clinical Physiology and Pharmacology
|October 30, 1998
PubMed
Summary

Selective brain cooling during heat stress creates an open-loop system for trunk temperature regulation. This study argues the set-point for temperature regulation is not raised during exercise, dehydration, or fever as previously thought.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corticotropin Releasing Hormone and Body Weight Regulation: The Behavioral Approach.

Nutritional neuroscience·2016
Same author

Alliesthesia in visual and auditory sensations from environmental signals.

Physiology & behavior·2007
Same author

Calcium deficiency cannot induce obesity in rats.

Physiology & behavior·2005
Same author

Chronic stress reduces body fat content in both obesity-prone and obesity-resistant strains of mice.

Hormones and behavior·2005
Same author

Influence of pellet size on rat's hoarding behavior.

Physiology & behavior·2004
Same author

Salicylate as a partial inhibitor of emotional fever and body weight set-point in rats: behavioral and neuroendocrine study.

Physiology & behavior·2003

Area of Science:

  • Physiology
  • Thermoregulation
  • Neuroscience

Background:

  • Selective brain cooling is a key thermoregulatory mechanism during heat stress.
  • This mechanism can lead to a dissociation between brain and core body temperatures.
  • Previous assumptions suggest a raised temperature set-point during various physiological conditions.

Purpose of the Study:

  • To investigate the influence of selective brain cooling on temperature regulation set-points.
  • To challenge the notion of a universally raised set-point during exercise, dehydration, and fever.
  • To analyze human experimental data for evidence supporting or refuting altered set-points.

Main Methods:

  • Analysis of human experimental data on thermoregulation.
  • Comparison of tympanic membrane and rectal temperature readings.

Related Experiment Videos

  • Evaluation of temperature regulation during heat stress, muscular exercise, dehydration, and fever.

    • Main Results:

    • Selective brain cooling results in an open-loop system for trunk core temperature.
    • Trunk core temperature deviates more significantly than brain temperature under heat stress.
    • The temperature set-point is not elevated during muscular exercise and dehydration when measured via tympanic membrane.
    • Fever-induced set-point elevation is less than suggested by rectal temperature readings.

    Conclusions:

    • Selective brain cooling impacts thermoregulation, creating a dissociation between brain and trunk temperatures.
    • The temperature regulation set-point is not consistently raised during exercise, dehydration, or fever.
    • Relying solely on rectal temperature may overestimate set-point changes in certain conditions.