Related Experiment Video
Updated: Aug 12, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
Published on: March 17, 2015
How significant is magnesium in thermoregulation?
G Stendig-Lindberg1, D Moran, Y Shapiro
1Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Hashomer, Israel.
Abstract:
Nine apparently healthy male subjects, mean age 22.8 yr, SD 4.1, free from disease, medication or addiction who gave informed consent, underwent acclimation process in a heat chamber; exposed during 2 h daily for 10 consecutive days to a temperature of 40 degrees C and 40% relative humidity while walking on a treadmill elevated by 3 degrees at a speed of 5 km/h (VO2 1.2 1.min-1). Serum, mononuclear and erythrocyte magnesium (S-Mg, M-Mg and E-Mg, respectively) were monitored on day 1, 5 and 10 before and after the heat exposure. S-Mg decreased while M-Mg increased after the heat exposures, suggesting a shift of S-Mg to mononuclear cells. The decrease of S-Mg was sustained at the end of the acclimation process. E-Mg increased up to day 5 and decreased gradually approximating the baseline by day 10. Mg appears to play a significant role in heat acclimation.
Related Concept Videos
Thermosensation
Body Temperature
Mechanism of heat transfer
Introduction to Electrolytes
Role of Sodium
One...
Body Temperature
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C (97–99°F), remaining relatively stable...
Mechanisms of Heat Transfer
Conduction, accounting for approximately 3% of body heat loss at rest, is the process of exchanging heat between molecules of two materials in direct contact. This can result in both heat loss and gain. For instance, when the body is submerged in water, which conducts heat 20 times more effectively than air, it can either lose or gain significant heat.

