Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inhibitory cytokines in asthma

P J Barnes1, S Lim

  • 1Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK. p.j.barnes@ic.ac.uk

Molecular Medicine Today
|October 30, 1998
PubMed
Summary

Defective expression of inhibitory cytokines like interleukin 10, interleukin 12, and interferon gamma may worsen asthma severity. Therapies using these cytokines could restore balance and treat severe or persistent allergic inflammation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glucocorticoid resistance in asthma.

American journal of respiratory and critical care medicine·1995
Same author

Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma.

The Journal of experimental medicine·1995
Same author

Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages.

Journal of immunology (Baltimore, Md. : 1950)·1995
Same author

Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.

Molecular pharmacology·1995
Same author

Corticosteroid inhibition of macrophage inflammatory protein-1 alpha in human monocytes and alveolar macrophages.

The American journal of physiology·1995
Same author

Cytokine expression in normal, atopic, and asthmatic subjects using the combination of sputum induction and the polymerase chain reaction.

Thorax·1995

Area of Science:

  • Immunology
  • Allergy Research
  • Respiratory Medicine

Background:

  • Asthma research often focuses on pro-inflammatory pathways.
  • Defective expression of inhibitory cytokines may significantly impact asthma severity and airway inflammation persistence.

Purpose of the Study:

  • To explore the role of inhibitory cytokines in asthma.
  • To discuss the therapeutic potential of these cytokines for severe or poorly responsive asthma.

Main Methods:

  • Review of existing research on cytokine expression in asthma.
  • Analysis of the therapeutic implications of inhibitory cytokines.

Main Results:

  • Inhibitory cytokines, including interleukin 10, interleukin 12, and interferon gamma, play a crucial role in regulating allergic inflammation.
  • Deficiencies in these cytokines can contribute to severe and persistent asthma.

Conclusions:

  • Therapies targeting inhibitory cytokines offer a promising approach for managing severe asthma.
  • Restoring endogenous cytokine balance may provide disease-modifying benefits, especially when initiated early.

Related Experiment Videos