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The intraocular penetration of dexamethasone after photorefractive keratectomy
M L McDermott1, S Vale, F Tayfour
1Kresge Eye Institute of Wayne State University, Detroit, MI 48201-1423, USA.
Background And Objective:
To determine the effect of photorefractive keratectomy (PRK) on intraocular steroid penetration.
Materials And Methods:
To assess steroid penetration after PRK, four rabbits underwent unilateral myopic 9.90-D PRK procedures. The other eye was left undisturbed as a control. One week later both eyes received hourly doses of radiolabeled topical dexamethasone.
Results:
No significant difference in corneal tissue [(mean +/- 1 SD) PRK 4.8 +/- 1.1 micrograms/g, control 5.2 +/- 1.2 micrograms/g] or aqueous humor concentration [(mean +/- 1 SD) PRK 0.8 +/- 0.12 microgram/ml, control 0.9 +/- 0.05 microgram/ml] of dexamethasone was seen.
Conclusions:
Dexamethasone penetration in eyes 1 week following PRK is similar to that of the unablated cornea.
