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Agreement between predicted risk and prevalence of Down syndrome in second-trimester triple-marker screening in Japan

T Onda1, T Tanaka, O Takeda

  • 1Jikei University School of Medicine, Tokyo, Japan.

Prenatal Diagnosis
|October 30, 1998
PubMed

Based on 9350 pregnant Japanese women who were screened by serum triple-marker determination, accuracy of predicted risk for Down syndrome was examined using 24 Down syndrome cases detected either prenatally or postnatally. The correlation is statistically very high (r = 0.98) between the predicted risks and the prevalence of Down syndrome cases. Here we emphasize that this could be accomplished only by an extensive follow-up study, implemented in our prospective intervention programme.

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