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Effects of magnesium orotate on exercise tolerance in patients with coronary heart disease
K R Geiss1, N Stergiou, Jester
1ISME (Private Research Institute for Sports, Medicine & Nutrition), Moerfelden, Germany.
Insights
Magnesium orotate supplementation improved cardiac function and exercise capacity in patients with coronary heart disease (CHD) and left-ventricular dysfunction. This pilot study demonstrated significant benefits in left ventricular volumes and exercise duration.
Area of Science:
- Cardiology
- Sports Medicine
- Nutritional Science
Background:
- Coronary heart disease (CHD) often leads to left-ventricular dysfunction.
- Impaired left ventricular function can limit exercise tolerance in patients with CHD.
- Ambulatory cardiac sports groups aim to improve cardiovascular health in affected individuals.
Purpose of the Study:
- To investigate the effects of magnesium orotate on left ventricular function and exercise capacity in patients with CHD and left-ventricular dysfunction.
- To assess changes in left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV).
- To evaluate the impact on ejection fraction (EF) and exercise duration.
Main Methods:
- A pilot study involving 14 patients with CHD and left-ventricular dysfunction.
- Patients participated in an ambulatory cardiac sports group.
- A 4-week double-blind treatment phase with either magnesium orotate (3x1g daily) or placebo, in addition to existing medication.
- Echocardiographic and ergometric tests were used for initial and concluding workups.
Main Results:
- Magnesium orotate significantly decreased LVESV (p=0.016) and tended to decrease LVEDV (p=0.054).
- Ejection fraction (EF) significantly increased (p=0.035) with magnesium orotate.
- Exercise duration significantly increased (p=0.011) in the magnesium orotate group.
Conclusions:
- Oral magnesium orotate shows favorable effects on left ventricular function in patients with CHD.
- Magnesium orotate supplementation can enhance exercise tolerance in this patient population.
- Further research is warranted to confirm these findings in larger cohorts.
Abstract:
In a pilot study at 14 patients with coronary heart disease (CHD) and left-ventricular dysfunction (left ventricular enddiastolic volume [LVEDV] > or = 100 ml), who actively participated in an ambulatory cardiac sports group, left ventricular endsystolic volume (LVESV), LVEDV and duration of exercise were analyzed by echocardiographic and ergometric tests. An initial workup was followed by a 4 week double blind treatment phase, in which magnesium orotate 3 x 1 g or placebo was given additionally to medication taken prior to the study. At the end of this phase a concluding workup was performed. Magnesium orotate decreased significantly (p = 0.016) LVESV, increased significantly (p = 0.035) EF, decreased in tendency (p = 0.054) LVEDV and increased significantly (p = 0.011) exercise duration. The study gives references to favourable effects of oral magnesium orotate to left ventricular function and exercise tolerance in patients with CHD.