Elaboration and evaluation of an intraoral controlled release delivering system
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Updated: Oct 27, 2026

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
Published on: March 17, 2008
Abstract:
In order to improve the administration of drugs for all pathology of the oral cavity, we have developed an intraoral controlled release delivering system, permitting to reach high enough local concentrations for desirable therapeutic effect with minimal side effects. We have formulated tablets of 200 mg intended to be fixed on a tooth. These tablets resist food and drink attacks. The tablets we elaborated have a granular matrix composed of hydroxyapatite, ethyl cellulose and Eudragit. Zinc sulfate is used as the first model of an active drug, it has a therapeutic effect on buccal mucous. Profiles of continuous in-vitro drug release in distilled water at 37 degrees C show that zinc sulfate release by the matrix structure for the different tablet formulations is regulated by the proportions of the different components.
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