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Related Experiment Videos

How to measure insulin sensitivity

E Ferrannini1, A Mari

  • 1CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy. ferranni@nsifc.ifc.pi.cnr.it

Journal of Hypertension
|October 30, 1998
PubMed
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Accurately measuring insulin resistance in vivo is crucial for assessing cardiovascular risk. This review details various methods, highlighting the euglycaemic insulin clamp as the gold standard for reliable insulin action assessment.

Area of Science:

  • Metabolic Physiology
  • Clinical Investigation
  • Cardiovascular Risk Assessment

Background:

  • Insulin resistance is prevalent and associated with metabolic disorders like glucose intolerance and dyslipidemia.
  • The insulin-resistant phenotype significantly impacts cardiovascular risk and treatment response.
  • Accurate in vivo measurement of insulin resistance is essential for clinical practice.

Purpose of the Study:

  • To review and compare various methods for measuring insulin resistance in vivo.
  • To discuss the merits, disadvantages, feasibility, and reliability of different techniques.
  • To provide guidance for selecting appropriate methods and reference data for clinical investigators.

Main Methods:

  • Euglycaemic insulin clamp (gold standard) for steady-state insulin action measurement.

Related Experiment Videos

  • Homeostatic model assessment (HOMA) using fasting glucose and insulin.
  • Other techniques: insulin suppression test, insulin tolerance test, intravenous glucose-tolerance test, constant infusion of glucose with model assessment.
  • Integration with tracer dilution, limb catheterization, calorimetry, PET, and NMR scans.

    • Main Results:

    • The euglycaemic insulin clamp offers precise, steady-state measures of insulin action.
    • Various methods exist, each with unique principles, advantages, and limitations.
    • The article compares techniques based on feasibility, reliability, and applicability.

    Conclusions:

    • The euglycaemic insulin clamp is the benchmark for measuring insulin resistance.
    • Understanding the principles and comparing techniques aids in selecting the most suitable method.
    • Accurate assessment of insulin resistance is vital for managing cardiovascular risk.