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Genetic dissection of glucocorticoid receptor function in mice
F Tronche1, C Kellendonk, H M Reichardt
1Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Federal Republic of Germany.
Current Opinion in Genetics & Development
|October 31, 1998
Summary
The activated glucocorticoid receptor (GR) acts as a transcription factor to regulate gene expression. Gene-targeting studies in mice reveal new insights into GR's in vivo functions and molecular mechanisms.
Area of Science:
- Molecular Biology
- Genetics
- Endocrinology
Background:
- The glucocorticoid receptor (GR) is a key transcription factor activated by hormone binding.
- GR regulates gene expression through various mechanisms.
- Understanding GR's in vivo functions is crucial for deciphering its role in cellular processes.
Purpose of the Study:
- To elucidate the in vivo functions of the glucocorticoid receptor (GR).
- To investigate the molecular mechanisms underlying GR's transcriptional regulation.
- To leverage recent gene-targeting studies for new insights into GR action.
Main Methods:
- Gene-targeting studies in mouse models.
- Analysis of gene expression patterns.
- Investigation of molecular mechanisms of transcription factor action.
Main Results:
- Gene-targeting studies provide novel insights into GR's in vivo roles.
- Specific molecular mechanisms of GR-mediated gene regulation are being deciphered.
- The findings highlight the complexity of GR's function in controlling gene expression.
Conclusions:
- Recent mouse studies have significantly advanced our understanding of glucocorticoid receptor (GR) function in vivo.
- Deciphering the molecular mechanisms of GR action is an ongoing area of research.
- These findings contribute to a deeper comprehension of hormonal regulation of gene expression.