Nasal obstruction caused by a pituitary chromophobe adenoma

Nasal obstruction as the only clinical manifestation of a pituitary tumor is rare. A case is reported of a 58-year-old white male with obstruction of the nose and nasopharynx due to a massive pituitary tumor, which recurred 21 years after primary radiation treatment. At autopsy, extensive destruction of the sphenoid and base of the skull was noted. Final pathologic diagnosis was Chromophobe Adenoma. Common clinical features of chromophobe adenomas are discussed.