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Related Experiment Videos

A novel co-crosslinked polysaccharide: studies for a controlled delivery matrix

T Coviello1, M Dentini, G Rambone

  • 1Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive. Università di Roma 'La Sapienza', 00185 Rome, Italy.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|October 31, 1998
PubMed
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A novel co-crosslinked polysaccharide (CCP) hydrogel was developed for controlled drug delivery. This innovative matrix offers tunable drug release, particularly with calcium ions, enhancing sustained delivery system performance.

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Pharmaceutical Sciences

Background:

  • Controlled drug delivery systems are crucial for therapeutic efficacy and patient compliance.
  • Polysaccharide-based hydrogels offer biocompatibility and tunable properties for drug encapsulation.
  • Developing novel matrices with modulated release profiles remains an active area of research.

Purpose of the Study:

  • To formulate a new controlled delivery system using a co-crosslinked polysaccharide (CCP) hydrogel.
  • To investigate the drug release characteristics of the CCP hydrogel and the influence of calcium ions.
  • To characterize the CCP hydrogel matrix and its diffusion properties.

Main Methods:

  • Chemical reaction in an aqueous medium to form a mixed physical gel of gellan and scleroglucan.

Related Experiment Videos

  • Preparation of co-crosslinked polysaccharide (CCP) hydrogel bearing carboxylic groups.
  • Diffusion experiments through the swelled hydrogel under various environmental conditions.
  • Evaluation of model drug release from CCP-based tablets, with and without CaCl2.

    • Main Results:

    • A novel CCP hydrogel was successfully synthesized, exhibiting sustained release behavior.
    • Drug release rate was significantly modulated by the presence of calcium ions.
    • Addition of CaCl2 to dosage forms further reduced the drug delivery rate due to interactions with carboxylic groups.
    • Differential behavior of Ca+2 and Na+ ions in modulating release was observed.

    Conclusions:

    • The developed CCP hydrogel is a promising matrix for controlled and sustained drug delivery.
    • Calcium ions play a key role in modulating the release kinetics of the CCP system.
    • The chemical structure of CCP, particularly its free ionized carboxylic groups, is responsible for the ion-dependent release modulation.