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Related Experiment Videos

Photostability of dithranol

K Thoma1, C Holzmann

  • 1Department of Pharmaceutical Technology, Ludwig-Maximilians-University, Munich, Germany. prof.thoma@Irz.uni-muenchen.de

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|October 31, 1998
PubMed
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Light exposure significantly impacts dithranol, an antipsoriatic drug, causing photodegradation. The rate of this degradation depends heavily on the specific excipient or solvent used in topical formulations.

Area of Science:

  • Photochemistry
  • Pharmaceutical Sciences
  • Dermatology

Background:

  • Dithranol is a key antipsoriatic drug.
  • Light exposure can affect drug stability.
  • Understanding dithranol's photodegradation is crucial for topical formulation efficacy.

Purpose of the Study:

  • To investigate the influence of light on dithranol.
  • To determine the rate and extent of dithranol photodegradation.
  • To assess the impact of different solvents and excipients on dithranol stability.

Main Methods:

  • Photodegradation studies using a Suntest CPS xenon lamp.
  • Analysis of dithranol content via High-Performance Liquid Chromatography (HPLC).
  • Characterization and identification of degradation products using diode array and HPLC-mass spectrometry.

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Main Results:

  • Dithranol undergoes significant photodegradation when exposed to light.
  • The rate and extent of degradation varied considerably based on the solvent or excipient.
  • Specific degradation products were identified, indicating complex photochemical reactions.

Conclusions:

  • The choice of excipient or solvent is critical for maintaining dithranol stability in topical formulations.
  • Light protection strategies are essential during the manufacturing and storage of dithranol products.
  • Further research into photostabilization of dithranol is warranted.