Related Experiment Videos
Up-regulation of thioredoxin expression in motor neurons after nerve injury
K Mansur1, Y Iwahashi, S Kiryu-Seo
1Department of Anatomy, Asahikawa Medical College, 4-5-3-11 Nishikagura, Asahikawa 078-8510, Japan.
Brain Research. Molecular Brain Research
|October 31, 1998
Abstract:
A substantial up-regulation of thioredoxin, a dithiol/disulfide oxido-reductase, in adult rat motoneurons following hypoglossal nerve axotomy, was demonstrated by using both in situ hybridization and immunohistochemistry. Although thioredoxin is normally accumulated more in the nucleus of a motoneuron rather than in the cytoplasm, a dramatic increase of thioredoxin in the cytoplasmic region after nerve injury was observed. The up-regulation of mRNA lasted more than 9 weeks, whereas, the detectable up-regulation of protein was observed for more than 5 weeks.