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Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1

D Morgan1, L Holcomb, I Saad

  • 1MDC Box 9, Alzheimer Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, FL 33612-4799, USA. dmorgan@pharm.med.usf.edu

Brain Research
|October 31, 1998
PubMed
Summary

Transgenic mice with heme oxygenase-1 (HO-1) showed impaired spatial navigation memory in the Morris water maze. Carbon monoxide from HO-1 activity may interfere with memory development.

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