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Cholesterol synthesis is increased in mixed hyperlipidaemia

R P Naoumova1, K D Kim, C Neuwirth

  • 1MRC Lipoprotein Team, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W2 ONN, UK. rnaoumov@rpms.ac.uk

Biochimica Et Biophysica Acta
|October 31, 1998
PubMed
Summary
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Cholesterol synthesis is elevated in patients with mixed hyperlipidaemia (type IIb), indicated by higher mevalonic acid (MVA) levels. This finding links increased cholesterol synthesis to mixed hyperlipidaemia, unlike primary hypercholesterolaemia (type IIa).

Area of Science:

  • Lipid metabolism and cardiovascular disease research.
  • Biochemistry and clinical diagnostics.

Background:

  • Previous studies linked hypertriglyceridaemia to increased cholesterol synthesis and apolipoprotein B secretion.
  • Hypercholesterolaemia alone was not previously correlated with these increases.

Purpose of the Study:

  • To compare cholesterol synthesis rates in primary mixed hyperlipidaemia (type IIb) versus primary hypercholesterolaemia (type IIa).
  • To use fasting plasma mevalonic acid (MVA) as a biomarker for cholesterol synthesis.

Main Methods:

  • Measured fasting plasma mevalonic acid (MVA) in patients with type IIb (n=45) and type IIa (n=92) hyperlipidaemia.
  • Compared MVA levels to 40 normolipidaemic controls.
  • Analyzed correlations between MVA, serum triglyceride, and LDL cholesterol levels.

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Main Results:

  • Type IIb patients showed significantly higher MVA levels compared to type IIa patients and controls.
  • LDL cholesterol was elevated in both type IIa and IIb compared to controls.
  • Serum triglyceride levels were significantly higher in type IIb compared to type IIa and controls.
  • Plasma MVA positively correlated with serum triglyceride and negatively with LDL cholesterol.

Conclusions:

  • Cholesterol synthesis is increased in patients with primary mixed hyperlipidaemia (type IIb).
  • These findings support the link between VLDL-apolipoprotein B secretion, cholesterol synthesis, and mixed hyperlipidaemia.
  • Increased cholesterol synthesis is a characteristic of mixed hyperlipidaemia.