Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Avoiding adverse drug effects in elderly patients

R M Leipzig1

  • 1Department of Geriatrics and Adult Development, Mount Sinai Medical Center, New York, USA.

Cleveland Clinic Journal of Medicine
|October 31, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does scopolamine directly impair memory?

Journal of cognitive neuroscience·2013
Same author

The restraint match-up. Three lessons show how nurse leaders can influence the use of physical restraints.

Nursing management·2004
Same author

Beyond interviewing skills: twelve steps for training interviewers.

Outcomes management for nursing practice·2002
Same author

Elderly patients' reports of physical restraint experiences in intensive care units.

American journal of critical care : an official publication, American Association of Critical-Care Nurses·2001
Same author

Methodologic issues in conducting research on hospitalized older people.

Journal of the American Geriatrics Society·2001
Same author

Prescribing. Keys to maximizing benefit while avoiding adverse drug effects.

Geriatrics·2001
Same journal

A 20-year-old woman with a 9-year history of shortness of breath.

Cleveland Clinic journal of medicine·2026
Same journal

A 70-year-old man with lower-extremity weakness and falls.

Cleveland Clinic journal of medicine·2026
Same journal

Treatment-refractory hypothyroidism: Don't just increase the dose.

Cleveland Clinic journal of medicine·2026
Same journal

In Reply: Beyond histologic improvement in MASH.

Cleveland Clinic journal of medicine·2026
Same journal

Comfort care: Creating a plan for hospitalized patients and their families.

Cleveland Clinic journal of medicine·2026
Same journal

Localized dead bone, a potential hint to an underlying condition.

Cleveland Clinic journal of medicine·2026
See all related articles

Commonly prescribed drugs can cause unexpected side effects in elderly patients due to altered drug responses. This review explores these issues and offers strategies for safer medication management in older adults.

Area of Science:

  • Geriatric Pharmacology
  • Clinical Pharmacy
  • Internal Medicine

Background:

  • The elderly population exhibits unique physiological changes affecting drug metabolism and response.
  • Standard drug dosages may not be appropriate for older adults, leading to adverse drug events.
  • Polypharmacy is common in the elderly, increasing the risk of drug interactions.

Purpose of the Study:

  • To elucidate the reasons behind altered drug responses in the elderly.
  • To identify factors contributing to unexpected medication effects in older patients.
  • To propose evidence-based recommendations for optimizing pharmacotherapy in geriatric populations.

Main Methods:

  • Comprehensive literature review of pharmacokinetic and pharmacodynamic changes in aging.

Related Experiment Videos

  • Analysis of clinical studies on drug efficacy and safety in elderly cohorts.
  • Synthesis of guidelines and expert opinions on geriatric prescribing.

    • Main Results:

    • Age-related declines in renal and hepatic function impact drug clearance.
    • Altered receptor sensitivity and reduced homeostatic mechanisms increase susceptibility to adverse effects.
    • Drug-drug and drug-disease interactions are prevalent and often underestimated.

    Conclusions:

    • Prescribing for the elderly requires careful consideration of individual patient factors and age-related physiological changes.
    • Dosage adjustments and selection of safer alternatives are crucial for improving medication outcomes.
    • Enhanced pharmacovigilance and interdisciplinary collaboration are essential for geriatric pharmacotherapy.