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Histology of anterior capsule fibrosis following phacoemulsification
A Caporossi1, F Casprini, G M Tosi
1Dipartimento di Scienze Oftalmologiche e Neurochirurgiche, Università degli Studi di Siena, Italy.
Purpose:
To determine the histology and immunohistochemistry of anterior capsule fibrosis.
Setting:
Department of Ophthalmology and Neurosurgery and Institute of Pathology, University of Siena, Siena, Italy.
Methods:
Tissue sections from 3 patients with anterior capsule fibrosis after phacoemulsification and intraocular lens implantation were examined histologically.
Results:
The proliferating tissue was devoid of vessels and composed of dense fibrous tissue and numerous activated fibroblasts with contractile capacity (myofibroblasts). No TGF-beta, which is the most important cytokine in modulating myofibroblasts, was present in the fibrotic tissue.
Conclusion:
The absence of the cytokine TGF-beta and inflammatory cells in the proliferating tissue confirms the unique character of the reparative activity within the eye.