Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calciphylaxis: a favorable outcome with hyperbaric oxygen

S M Dean1, H Werman

  • 1Grant Wound Care Center, Grant Hospital, Columbus, OH, USA.

Vascular Medicine (London, England)
|October 31, 1998
PubMed
Summary

Calciphylaxis, a rare condition causing skin ulcers in patients with kidney disease, can be effectively treated with hyperbaric oxygen therapy. This treatment significantly improved painful lower extremity ulcers in a patient with end-stage renal disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trimers Conjugated to Fibrin Hydrogels Promote Salivary Gland Function.

Journal of dental research·2020
Same author

Storm-induced sea-ice breakup and the implications for ice extent.

Nature·2014
Same author

Three cases of digital ischemia successfully treated with cilostazol.

Vascular medicine (London, England)·2002
Same author

Phenanthrene degradation in soils co-inoculated with phenanthrene-degrading and biosurfactant-producing bacteria.

Journal of environmental quality·2001
Same author

Images in vascular medicine. Elephantiasis nostras verrucosa.

Vascular medicine (London, England)·2001
Same author

Air medical transport of the injured patient: scene versus referring hospital.

Air medical journal·1998

Area of Science:

  • Nephrology
  • Dermatology
  • Vascular Medicine

Background:

  • Calciphylaxis is a severe complication of end-stage renal disease (ESRD)
  • It is characterized by painful skin necrosis and ulcerations
  • Associated with abnormal calcium and phosphate metabolism

Observation:

  • A 66-year-old female with diabetes mellitus and ESRD presented with painful livedo reticularis and necrotic lower extremity ulcers.
  • Vascular studies showed intact pulses and normal large vessel perfusion.
  • Laboratory findings revealed elevated calcium x phosphorous product and parathyroid hormone levels.

Findings:

  • Biopsy confirmed medial calcinosis of small vessels, leading to a diagnosis of calciphylaxis.
  • Standard treatments including wound debridement, antibiotics, and subtotal parathyroidectomy provided limited improvement.

Related Experiment Videos

  • Hyperbaric oxygen therapy (HBOT) was initiated due to refractory symptoms.

    • Implications:

    • Seven weeks of HBOT resulted in near-complete healing of the patient's calciphylaxis-related ulcers.
    • This case highlights HBOT as a potential therapeutic option for calciphylaxis.
    • Further research into HBOT's role in managing calciphylaxis is warranted.