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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.2K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.2K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

9.1K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
9.1K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

8.9K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.5K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.5K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.9K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.9K
Selectins01:25

Selectins

4.1K
Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Related Experiment Videos

[Cell adhesion molecule]

H Ikeda1

  • 1Third Department of Internal Medicine, Kurume University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|October 31, 1998
PubMed
Summary
This summary is machine-generated.

Platelet aggregation, crucial in acute coronary syndromes, involves cell adhesion molecules. Understanding platelet glycoprotein Ib, IIb/IIIa, and P-selectin roles can lead to better treatments.

Related Experiment Videos

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Molecular Biology

Context:

  • Acute coronary syndromes (ACS) pathophysiology involves platelet aggregation and thrombus formation.
  • Plaque disruption in coronary atheroma initiates thrombotic events.
  • Cell adhesion molecules are fundamental to ACS pathogenesis.

Purpose:

  • To review the critical roles of specific platelet adhesion molecules in thrombus formation.
  • To elucidate the function of platelet glycoprotein Ib, IIb/IIIa, and P-selectin in thrombotic processes.
  • To highlight how understanding these molecules can advance ACS therapeutic strategies.

Summary:

  • Platelet aggregation and thrombus formation are central to acute coronary syndromes, often triggered by atherosclerotic plaque rupture.
  • Cell adhesion molecules mediate essential cell-extracellular matrix and cell-cell interactions during initial thrombus formation at culprit lesions.
  • This review specifically examines the involvement of platelet glycoprotein Ib, glycoprotein IIb/IIIa, and P-selectin in the thrombotic cascade.

Impact:

  • Enhanced understanding of platelet adhesion molecule function can guide the development of novel anti-thrombotic therapies.
  • Targeting specific platelet glycoproteins may offer more effective treatment strategies for acute coronary syndromes.
  • This review provides a foundation for future research into molecular mechanisms of atherothrombosis.