Related Experiment Video
Updated: Jul 9, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
[The role of nitric oxide in ischemia-reperfused heart]
M Nishida1, J Igarashi, T Kuzuya
1Osaka University Medical School, Department of Medicine and Pathophysiology.
Abstract:
We examined the role of nitric oxide (NO) in ischemia-reperfused hearts. In an occlusion-reperfusion model of hypercholesterolemic rabbits, the extent of myocardial infarction was increased because of the activation of neutrophils, possibly due to the impaired production of NO in atherosclerotic coronary circulation. It was reversed by the addition of exogenous NO releaser, SNAP. In a hypoxia-reoxygenation model of cultured cardiac myocytes, NO produced by endogenous cardiac iNOS augmented myocyte injury after exposure to hypoxia-reoxygenation. Inhibition of glutathione peroxidase activity was suggested to be the mechanism of sensitization to oxidative stress after exposure to NO. Therefore, NO is supposed to play two roles in ischemia-reperfused hearts, i.e., cardioprotective effect through coronary circulation and cardiotoxic effect through direct action on cardiac myocytes.
Related Concept Videos
Nitric Oxide Signaling Pathway
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Coronary Artery Disease V: Interprofessional Care
Acute Coronary Syndrome IV: Interprofessional Care
Ischemic Stroke ll: Pathophysiology

