Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simultaneous increases in respiration and sympathetic function during opiate detoxification

W E Hoffman1, T McDonald, R Berkowitz

  • 1Department of Anesthesiology, University of Illinois at Chicago, 60612, USA.

Journal of Neurosurgical Anesthesiology
|October 31, 1998
PubMed
Summary

Naltrexone treatment in opioid-dependent patients increased sympathetic activity and spontaneous ventilation. Peak sympathetic and respiratory stimulation occurred together during opiate receptor antagonism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic risk-targeted islet autoantibody screening for presymptomatic type 1 diabetes in adults.

The lancet. Diabetes & endocrinology·2025
Same author

Physiotherapy interventions for the respiratory management of people with spinal cord injury: recommendations from an Australian and New Zealand clinical practice guideline.

Spinal cord·2025
Same author

Peer-led exercise program for ageing adults to improve physical functions - a randomized trial.

European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity·2021
Same author

Quo Vadis? A question of historical awareness.

International nursing review·2020
Same author

Correction to: Trend estimation for complex survey designs of water chemistry indicators from Sierra Nevada Lakes.

Environmental monitoring and assessment·2018
Same author

Trend estimation for complex survey designs of water chemistry indicators from Sierra Nevada Lakes.

Environmental monitoring and assessment·2018

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Neuroscience

Background:

  • Opioid dependence poses significant clinical challenges, particularly during anesthesia.
  • Understanding the physiological responses to opioid antagonists like naltrexone is crucial for patient management.

Purpose of the Study:

  • To investigate the relationship between sympathetic nervous system activity and spontaneous ventilation during naltrexone administration in opioid-dependent patients.
  • To assess the impact of naltrexone on autonomic and respiratory parameters under propofol anesthesia.

Main Methods:

  • 16 opioid-dependent patients received escalating doses of naltrexone via orogastric tube during propofol anesthesia.
  • Sympathetic activity was assessed using low-frequency heart rate variability (0.02-0.10 Hz).

Related Experiment Videos

  • Minute ventilation was measured, and electroencephalogram activity was monitored using the bispectral index.

    • Main Results:

    • Naltrexone administration led to a five-fold increase in sympathetic activity and a 50% increase in minute ventilation.
    • Heart rate and blood pressure elevated, while the bispectral index remained unchanged.
    • A strong positive correlation (r = 0.83, p < 0.001) was observed between peak sympathetic response and peak ventilation.
    • Control patients receiving anesthesia without naltrexone showed no significant changes in sympathetic or respiratory parameters.

    Conclusions:

    • Naltrexone treatment significantly stimulates both sympathetic and respiratory systems in opioid-dependent patients.
    • Peak sympathetic and respiratory responses coincide during opiate receptor antagonism.
    • These findings highlight the potent physiological effects of naltrexone in this patient population.