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Updated: Oct 5, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
[Dinitrochlorobenzene test in patients with chronic nephritis]
Abstract:
Dinitrochlorobenzene (DNCB) test was applied to 22 patients with chronic nephritis. Only 22% of the patients gave positive results. This was concluded to be due to the high NPN levels. It was demonstrated that this inhibition is transitory and the normal responses appear 12 hours after the return of the NPN to normal levels. When it was considered that some patients with high NPN levels showed normal DNCB reactivity and delayed rejection time, the chronic nephritis patiens reacted to organ transplants despite their normal NPN levels. It was suggested that it is one of the components of NPN which should be responsible for the above mentioned inhibition.
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