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Related Experiment Videos

Transient hyperandrogenemia and its relation to ovulation

J M Martins1, F Carreiras, A Afonso

  • 1Endocrine Unit, Curry Cabral Hospital, Lisbon, Portugal.

Fertility and Sterility
|October 31, 1998
PubMed
Summary

Transient hyperandrogenemia, common in hirsute women, occurs differently in ovulatory versus anovulatory cycles. Understanding its timing relative to ovulation is crucial for effective hirsutism treatment.

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Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Women's Health

Background:

  • Hyperandrogenemia is frequently observed in women with hirsutism.
  • The temporal relationship between androgen levels and ovulatory status requires further elucidation.

Purpose of the Study:

  • To investigate the association between serum androgen levels and ovulation in young, nonobese, hirsute women.
  • To differentiate patterns of hyperandrogenemia in relation to ovulatory and anovulatory cycles.

Main Methods:

  • Prospective, controlled clinical study involving 48 hirsute women.
  • Endocrine evaluation during early follicular and late luteal phases of spontaneous menstrual cycles.
  • Measurement of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), androstenedione (A), total testosterone (T), dehydroepiandrosterone sulfate (DHEAS), and 17alpha-hydroxyprogesterone (17-OHP).

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Main Results:

  • Hyperandrogenemia presented as persistent (56%) or transient (44%) forms.
  • Transient hyperandrogenemia occurred in the early follicular phase of ovulatory cycles (63%) and the second phase of delayed/anovulatory cycles (90%).
  • In delayed/anovulatory cycles, androstenedione, total testosterone, and DHEAS levels significantly increased during the follicular phase.

Conclusions:

  • Transient hyperandrogenemia in delayed/anovulatory cycles is linked to ineffective steroidogenesis late in the follicular phase.
  • In ovulatory cycles, transient hyperandrogenemia in the early follicular phase is attenuated post-ovulation by aromatization.
  • Physicians should consider transient hyperandrogenemia's cyclical nature when managing hirsutism.